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James O McNamara Selected Research

trkB Receptor

11/2015A Peptide Uncoupling BDNF Receptor TrkB from Phospholipase Cγ1 Prevents Epilepsy Induced by Status Epilepticus.
7/2013Transient inhibition of TrkB kinase after status epilepticus prevents development of temporal lobe epilepsy.
1/2008Altered morphology of hippocampal dentate granule cell presynaptic and postsynaptic terminals following conditional deletion of TrkB.
1/2004Ontogeny of seizure-induced increases in BDNF immunoreactivity and TrkB receptor activation in rat hippocampus.

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James O McNamara Research Topics

Disease

10Epilepsy (Aura)
11/2021 - 01/2008
9Seizures (Absence Seizure)
12/2021 - 10/2002
8Status Epilepticus (Complex Partial Status Epilepticus)
12/2021 - 01/2003
8Neoplasms (Cancer)
09/2017 - 12/2005
4Temporal Lobe Epilepsy
01/2022 - 07/2013
3Neoplasm Metastasis (Metastasis)
09/2017 - 12/2005
2Breast Neoplasms (Breast Cancer)
09/2017 - 07/2012
2Febrile Seizures (Febrile Seizure)
12/2016 - 06/2015
2Prostatic Neoplasms (Prostate Cancer)
09/2009 - 08/2006
1Treatment-Resistant Depressive Disorder
01/2017
1Partial Epilepsies (Epilepsy, Partial)
01/2017
1Urinary Tract Infections (Urinary Tract Infection)
01/2017
1Edema (Dropsy)
12/2016
1Infections
01/2014
1Microcephaly
10/2013
1Brain Diseases (Brain Disorder)
10/2013
1Nervous System Diseases (Neurological Disorders)
10/2012
1Juvenile Myoclonic Epilepsy
08/2012
1Idiopathic Generalized Epilepsy
08/2012
1Absence Epilepsy (Childhood Absence Epilepsy)
08/2012
1Ischemia
10/2002
1Neurodegenerative Diseases (Neurodegenerative Disease)
10/2002

Drug/Important Bio-Agent (IBA)

4Kainic Acid (Kainate)IBA
12/2021 - 01/2003
4Proteins (Proteins, Gene)FDA Link
11/2021 - 02/2003
4trkB ReceptorIBA
11/2015 - 01/2004
3Brain-Derived Neurotrophic Factor (BDNF)IBA
01/2020 - 01/2004
3Nucleotide AptamersIBA
07/2012 - 09/2009
2fibroblast growth factor 13IBA
12/2016 - 06/2015
2Neuroprotective AgentsIBA
11/2015 - 10/2012
2RNA (Ribonucleic Acid)IBA
07/2012 - 09/2009
2LigandsIBA
07/2012 - 10/2011
2AntigensIBA
10/2011 - 09/2009
2Small Interfering RNA (siRNA)IBA
09/2009 - 08/2006
2Complement System Proteins (Complement)IBA
02/2003 - 10/2002
1ProteomeIBA
11/2021
1Nucleic Acid ProbesIBA
09/2017
1Biomarkers (Surrogate Marker)IBA
09/2017
1Oligonucleotide ProbesIBA
01/2017
1Deoxyribonuclease I (Nickase)IBA
01/2017
1Protein Isoforms (Isoforms)IBA
12/2016
1tyrosine receptor (receptor, tyrosine)IBA
11/2015
1Phospholipases (Phospholipase)IBA
11/2015
1Peptides (Polypeptides)IBA
11/2015
1Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA
08/2014
1TamoxifenFDA LinkGeneric
08/2014
1Deoxyribonucleases (DNase)FDA Link
01/2014
1EnzymesIBA
01/2014
1Virulence Factors (Pathogenicity Factors)IBA
01/2014
1Aspartate-Ammonia Ligase (Asparagine Synthetase)IBA
10/2013
1Phosphotransferases (Kinase)IBA
07/2013
1Immunoglobulin E (IgE)IBA
08/2012
1NucleotidesIBA
08/2012
1Trastuzumab (Herceptin)FDA Link
07/2012
1Cisplatin (Platino)FDA LinkGeneric
07/2012
1human ERBB2 proteinIBA
07/2012
1AntibodiesIBA
10/2011
1Surface Antigens (Surface Antigen)IBA
10/2011
1OligonucleotidesIBA
10/2011
1Pharmaceutical PreparationsIBA
10/2011
1Green Fluorescent ProteinsIBA
01/2010
1Pilocarpine (Ocusert)FDA LinkGeneric
01/2010
1Polyethylene Glycols (Polyethylene Glycol)FDA LinkGeneric
09/2009
1Pentylenetetrazole (Metrazol)IBA
09/2008
1Potassium Channels (Potassium Channel)IBA
09/2008
1Dihydrotachysterol (AT 10)IBA
09/2008
1N- (6- Chloropyridin- 3- yl)- 3,4- difluorobenzamideIBA
09/2008
12-Amino-5-phosphonovalerate (2 Amino 5 phosphonovalerate)IBA
10/2006
1Excitatory Amino Acid AntagonistsIBA
10/2006
1BuffersIBA
10/2006
1Cell Surface ReceptorsIBA
08/2006
1Indicators and Reagents (Reagents)IBA
08/2006
1Integrin alphaVbeta3IBA
12/2005
1Complement Membrane Attack Complex (Membrane Attack Complex)IBA
02/2003
1Semaphorins (Semaphorin)IBA
01/2003
1Complementary DNA (cDNA)IBA
01/2003
1Glutamate Receptors (Glutamate Receptor)IBA
10/2002

Therapy/Procedure

7Therapeutics
01/2022 - 08/2006
2Vagus Nerve Stimulation
01/2017 - 11/2012
2Induced Hyperthermia (Thermotherapy)
12/2016 - 06/2015
1Drug Therapy (Chemotherapy)
07/2012